A Prospective Cohort Study. Purpose : Increasing numbers of blood transfusions and higher mean arterial oxygen saturation have both been associated with increased risk of retinopathy of prematurity ROP. Blood transfusion with adult haemoglobin HbA replaces foetal haemoglobin HbF. HbA has a lower affinity for oxygen than HbF and therefore leads to increased oxygen availability to the tissues including the retina. We hypothesize that the sudden increase in oxygen availability after blood transfusion could be a cause of the capillary obliteration phase of ROP via downregulation of VEGF and associated angiogenic factors and contribute to the development of ROP.
We go on to discuss strategies by which such approaches may be developed. Older studies in this field can provide important lessons for future studies aimed at developing more effective strategies for HbF induction, and we therefore chronologically cover the work accomplished as this field has evolved over the course of the past four decades. As with many facets of the history of the hemoglobin field, the study of the fetal-to-adult hemoglobin switch and work on fetal hemoglobin silencing has a rich and storied history that spans the course of several decades. In this work, we begin with a historic overview of this field and then move on to discuss more recent molecular findings that are providing important new insight into this process. There is great hope that these new molecular studies may lead to important targeted therapeutic advances for fetal hemoglobin HbF induction.
Jump to content. A hemoglobin electrophoresis test is a blood test done to check the different types of hemoglobin in the blood. Hemoglobin is the substance in red blood cells that carries oxygen. There are more than types of abnormal hemoglobin. Hemoglobin S and hemoglobin C are the most common types of abnormal hemoglobin that may be found by an electrophoresis test.