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Skip to main content Skip to table of contents. Advertisement Hide. This service is more advanced with JavaScript available. Critical Dietary Factors in Cancer Chemoprevention. Front Matter Pages i-xv.
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The Birt–Hogg–Dubé tumor suppressor Folliculin negatively regulates ribosomal RNA synthesis

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Critical Dietary Factors in Cancer Chemoprevention | SpringerLink

We further show that human FLCN exhibited evolutionarily conserved function and that Rpt4 knockdown inhibits the growth of FLCN-deficient human renal cancer cells in mouse xenografts. Although it displays no significant homology to any known human proteins, FLCN is widely conserved across species, suggesting a crucial biological function 6. In normal human tissues, FLCN mRNA expression was observed in various organs and cell types, including the stromal cells and type 1 pneumocytes of the lung, the distal nephron of the kidney, the macrophages and lymphocytes in the tonsils and spleen and the skin and its appendages 7. Recently, several genetic and biochemical studies have attempted to understand the molecular function of FLCN. However, some other studies have reported opposing effects of FLCN's downregulation on phosphorylated ribosomal protein S6 p-S6 signaling cascade In contrast, generation of kidney-specific homozygous knockout of FLCN mice, however, led to the development of polycystic kidneys and increased p-S6 16 , These findings were especially surprising because both BHD syndrome and TSC disorder have highly similar disease symptomatology, i.
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Critical Dietary Factors in Cancer Chemoprevention

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